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MAP .mitogen-activated protein PI3K phosphatidylinositol 3-kinase PKC protein kinase C CK2 casein kinase-2 Nrf2 After migration to the nucleus, Nrf2 undergoes heterodimeric combinations with other transcription factors, such as small Maf protein and binds to the 5-upstream cis-acting antioxidant regulatory sequence ARE or electrophile response elements (EpRE), located in the promoter region of genes encoding various antioxidant/detoxifying enzymes

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